Drug interactions
Fludrocortisone + Primidone
Severity: Moderate
Fludrocortisone and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital, which induces CYP3A4 and can speed the clearance of corticosteroids. This may reduce fludrocortisone effect and compromise mineralocorticoid replacement.
What this interaction means in plain words
Fludrocortisone and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Primidone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by primidone and its metabolite phenobarbital.
What to do
Monitor blood pressure and serum electrolytes and increase the fludrocortisone dose if replacement appears inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Fludrocortisone with Primidone?
MediHelp rates the interaction as moderate. Fludrocortisone and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital, which induces CYP3A4 and can speed the clearance of corticosteroids. This may reduce fludrocortisone effect and compromise mineralocorticoid replacement.
How serious is the interaction between Fludrocortisone and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum electrolytes and increase the fludrocortisone dose if replacement appears inadequate.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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