Drug interactions
Fludrocortisone + Somapacitan
Severity: Moderate
Fludrocortisone and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, reducing conversion of cortisone to active cortisol. Patients with adrenal insufficiency may therefore need higher glucocorticoid replacement after starting somapacitan, and excess glucocorticoid can blunt growth response. Fludrocortisone has mainly mineralocorticoid effect, so the impact is mostly relevant to concurrent hydrocortisone or cortisone.
What this interaction means in plain words
Fludrocortisone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone inhibition of 11-beta-HSD1 lowers cortisol regeneration, and glucocorticoids oppose growth-promoting effects.
What to do
Reassess glucocorticoid replacement after starting somapacitan and adjust doses clinically; monitor growth and adrenal status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Fludrocortisone with Somapacitan?
MediHelp rates the interaction as moderate. Fludrocortisone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, reducing conversion of cortisone to active cortisol. Patients with adrenal insufficiency may therefore need higher glucocorticoid replacement after starting somapacitan, and excess glucocorticoid can blunt growth response. Fludrocortisone has mainly mineralocorticoid effect, so the impact is mostly relevant to concurrent hydrocortisone or cortisone.
How serious is the interaction between Fludrocortisone and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reassess glucocorticoid replacement after starting somapacitan and adjust doses clinically; monitor growth and adrenal status.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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