Drug interactions
Fludrocortisone + Tolmetin
Severity: Moderate
Fludrocortisone and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids taken with NSAIDs raise the risk of gastrointestinal ulceration and bleeding. Fludrocortisone's mineralocorticoid effects may also add to fluid retention and blood pressure elevation with NSAIDs.
What this interaction means in plain words
Fludrocortisone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive mucosal injury from NSAID prostaglandin inhibition and corticosteroid effects, plus additive sodium and fluid retention.
What to do
Monitor blood pressure, edema and GI symptoms, and consider gastroprotection in at-risk patients. Keep NSAID duration short.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Tolmetin?
MediHelp rates the interaction as moderate. Fludrocortisone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids taken with NSAIDs raise the risk of gastrointestinal ulceration and bleeding. Fludrocortisone's mineralocorticoid effects may also add to fluid retention and blood pressure elevation with NSAIDs.
How serious is the interaction between Fludrocortisone and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and GI symptoms, and consider gastroprotection in at-risk patients. Keep NSAID duration short.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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