Drug interactions
Flunisolide inhaled + Mifepristone
Severity: Moderate
Flunisolide inhaled and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase systemic exposure to inhaled flunisolide. This raises the possibility of corticosteroid systemic effects. Mifepristone also blocks glucocorticoid receptors, which may blunt the corticosteroid effect.
What this interaction means in plain words
Flunisolide inhaled and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of flunisolide and also antagonizes glucocorticoid receptors.
What to do
Monitor for systemic corticosteroid effects and for loss of asthma control. Use the lowest effective flunisolide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Flunisolide inhaled with Mifepristone?
MediHelp rates the interaction as moderate. Flunisolide inhaled and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase systemic exposure to inhaled flunisolide. This raises the possibility of corticosteroid systemic effects. Mifepristone also blocks glucocorticoid receptors, which may blunt the corticosteroid effect.
How serious is the interaction between Flunisolide inhaled and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid effects and for loss of asthma control. Use the lowest effective flunisolide dose.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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