Drug interactions
Fluorouracil + Terbinafine
Severity: Minor
Fluorouracil and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic fluorouracil is not a clinically important inhibitor of terbinafine metabolism. Both agents can cause liver enzyme elevations, so overlapping hepatotoxicity is the only plausible concern.
What this interaction means in plain words
Fluorouracil and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluorouracil belongs to Oncology; Terbinafine belongs to Anti Fungals.
Why it happens
No established pharmacokinetic mechanism; possible additive hepatotoxicity only.
What to do
Check liver function tests at baseline and periodically if both are used, and stop terbinafine if hepatic injury occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Fluorouracil
Frequently asked questions
Can I take Fluorouracil with Terbinafine?
MediHelp rates the interaction as minor. Fluorouracil and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic fluorouracil is not a clinically important inhibitor of terbinafine metabolism. Both agents can cause liver enzyme elevations, so overlapping hepatotoxicity is the only plausible concern.
How serious is the interaction between Fluorouracil and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver function tests at baseline and periodically if both are used, and stop terbinafine if hepatic injury occurs.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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