Drug interactions
Fluoxetine + Gabapentin
Severity: Minor
Fluoxetine and Gabapentin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, and gabapentin carries a warning for respiratory depression when combined with other CNS depressants. The clinical significance is usually modest in otherwise healthy patients, but greater in the elderly or those with respiratory disease.
What this interaction means in plain words
Fluoxetine and Gabapentin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Gabapentin belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Use the lowest effective gabapentin dose and monitor for sedation, and for respiratory depression in high-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Fluoxetine with Gabapentin?
MediHelp rates the interaction as minor. Fluoxetine and Gabapentin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause drowsiness and dizziness, and gabapentin carries a warning for respiratory depression when combined with other CNS depressants. The clinical significance is usually modest in otherwise healthy patients, but greater in the elderly or those with respiratory disease.
How serious is the interaction between Fluoxetine and Gabapentin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective gabapentin dose and monitor for sedation, and for respiratory depression in high-risk patients.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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