Drug interactions
Fluoxetine + Glibenclamide
Severity: Moderate
Fluoxetine and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can enhance glucose-lowering and has been associated with hypoglycemia in patients using antidiabetic drugs. Combined with glyburide, a long-acting sulfonylurea, the risk of prolonged hypoglycemia may be increased.
What this interaction means in plain words
Fluoxetine and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Glibenclamide belongs to Endocrine.
Why it happens
Possibly improved insulin sensitivity and altered glucose regulation from fluoxetine; the mechanism is not fully established.
What to do
Monitor blood glucose more closely when fluoxetine is started, changed or stopped. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Fluoxetine with Glibenclamide?
MediHelp rates the interaction as moderate. Fluoxetine and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can enhance glucose-lowering and has been associated with hypoglycemia in patients using antidiabetic drugs. Combined with glyburide, a long-acting sulfonylurea, the risk of prolonged hypoglycemia may be increased.
How serious is the interaction between Fluoxetine and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely when fluoxetine is started, changed or stopped. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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