Drug interactions
Fluoxetine + Indacaterol inhaled
Severity: Moderate
Fluoxetine and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta2 agonists can cause tachycardia, hypokalemia and QT prolongation, which may add to the QT effect of fluoxetine. Clinically significant events are uncommon at inhaled doses but possible in patients with cardiac risk factors.
What this interaction means in plain words
Fluoxetine and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization, with beta2-mediated hypokalemia and sympathetic stimulation.
What to do
Monitor heart rate, ECG and potassium in patients with cardiac disease or other QT risk factors. Do not exceed the recommended indacaterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Fluoxetine and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta2 agonists can cause tachycardia, hypokalemia and QT prolongation, which may add to the QT effect of fluoxetine. Clinically significant events are uncommon at inhaled doses but possible in patients with cardiac risk factors.
How serious is the interaction between Fluoxetine and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium in patients with cardiac disease or other QT risk factors. Do not exceed the recommended indacaterol dose.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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