Drug interactions
Fluoxetine + Indapamide
Severity: Moderate
Fluoxetine and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can modestly prolong the QT interval, and indapamide can add risk by causing hypokalemia and hypomagnesemia. Fluoxetine may also contribute to hyponatremia in combination with diuretics.
What this interaction means in plain words
Fluoxetine and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Indapamide belongs to Cardiovascular.
Why it happens
Additive QT effects, with diuretic-induced electrolyte loss and additive hyponatremia risk.
What to do
Monitor sodium, potassium and magnesium after starting the combination, particularly in older patients. Obtain an ECG if other QT-prolonging risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Indapamide?
MediHelp rates the interaction as moderate. Fluoxetine and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can modestly prolong the QT interval, and indapamide can add risk by causing hypokalemia and hypomagnesemia. Fluoxetine may also contribute to hyponatremia in combination with diuretics.
How serious is the interaction between Fluoxetine and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sodium, potassium and magnesium after starting the combination, particularly in older patients. Obtain an ECG if other QT-prolonging risk factors are present.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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