Drug interactions
Fluoxetine + Ketorolac intranasal
Severity: Major
Fluoxetine and Ketorolac intranasal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs impair platelet aggregation, and ketorolac is an NSAID that inhibits platelets and can injure the gastrointestinal mucosa. Together they increase the risk of gastrointestinal and other bleeding. Ketorolac is a particularly potent NSAID for this risk.
What this interaction means in plain words
Fluoxetine and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effects: SSRI-induced platelet serotonin depletion plus NSAID inhibition of cyclooxygenase and mucosal protection.
What to do
Avoid combining where possible and keep ketorolac use short; if combined, monitor for bleeding and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Ketorolac intranasal?
MediHelp rates the interaction as major. Fluoxetine and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. SSRIs impair platelet aggregation, and ketorolac is an NSAID that inhibits platelets and can injure the gastrointestinal mucosa. Together they increase the risk of gastrointestinal and other bleeding. Ketorolac is a particularly potent NSAID for this risk.
How serious is the interaction between Fluoxetine and Ketorolac intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and keep ketorolac use short; if combined, monitor for bleeding and consider gastroprotection.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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