Drug interactions
Fluoxetine + Lamotrigine
Severity: Minor
Fluoxetine and Lamotrigine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lamotrigine and fluoxetine are often used together without major problems, but additive CNS effects such as drowsiness, dizziness and impaired coordination can occur. Both agents may also affect seizure threshold or mood stability, so clinical response should be followed.
What this interaction means in plain words
Fluoxetine and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Lamotrigine belongs to Central Nervous System.
Why it happens
Additive CNS effects; no well-established pharmacokinetic mechanism.
What to do
Monitor for sedation and psychomotor impairment, and advise caution when driving after starting or adjusting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Lamotrigine
Frequently asked questions
Can I take Fluoxetine with Lamotrigine?
MediHelp rates the interaction as minor. Fluoxetine and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lamotrigine and fluoxetine are often used together without major problems, but additive CNS effects such as drowsiness, dizziness and impaired coordination can occur. Both agents may also affect seizure threshold or mood stability, so clinical response should be followed.
How serious is the interaction between Fluoxetine and Lamotrigine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and psychomotor impairment, and advise caution when driving after starting or adjusting either drug.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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