Drug interactions
Fluoxetine + Levosalbutamol
Severity: Moderate
Fluoxetine and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can prolong the QT interval and beta2-agonists such as levosalbutamol can cause tachycardia, hypokalemia and QT prolongation at higher doses. Together they may add to the risk of arrhythmia, particularly with high doses, hypokalemia or other risk factors.
What this interaction means in plain words
Fluoxetine and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Levosalbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation from fluoxetine and beta2-agonist effects, with beta2-induced hypokalemia increasing susceptibility.
What to do
Monitor ECG and serum potassium in patients with cardiac disease, electrolyte disturbance or other QT-prolonging drugs. Avoid excessive levosalbutamol dosing and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Levosalbutamol?
MediHelp rates the interaction as moderate. Fluoxetine and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can prolong the QT interval and beta2-agonists such as levosalbutamol can cause tachycardia, hypokalemia and QT prolongation at higher doses. Together they may add to the risk of arrhythmia, particularly with high doses, hypokalemia or other risk factors.
How serious is the interaction between Fluoxetine and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients with cardiac disease, electrolyte disturbance or other QT-prolonging drugs. Avoid excessive levosalbutamol dosing and correct hypokalemia.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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