Drug interactions
Fluoxetine + Meclofenamate
Severity: Moderate
Fluoxetine and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs impair platelet function and NSAIDs irritate the gastric mucosa and inhibit platelet aggregation, so together they increase the risk of gastrointestinal and other bleeding. The risk is greater in older patients and those with ulcer history or on anticoagulants.
What this interaction means in plain words
Fluoxetine and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: SSRI-induced depletion of platelet serotonin plus NSAID inhibition of platelet cyclooxygenase and mucosal protection.
What to do
Monitor for signs of GI bleeding and consider a proton pump inhibitor for gastroprotection in at-risk patients. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Meclofenamate?
MediHelp rates the interaction as moderate. Fluoxetine and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs impair platelet function and NSAIDs irritate the gastric mucosa and inhibit platelet aggregation, so together they increase the risk of gastrointestinal and other bleeding. The risk is greater in older patients and those with ulcer history or on anticoagulants.
How serious is the interaction between Fluoxetine and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and consider a proton pump inhibitor for gastroprotection in at-risk patients. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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