Drug interactions
Fluoxetine + Mipomersen
Severity: Moderate
Fluoxetine and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises transaminases and can cause hepatic steatosis. Fluoxetine has been associated with occasional liver enzyme elevations, so additive hepatotoxic potential is possible.
What this interaction means in plain words
Fluoxetine and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive hepatotoxicity; no specific pharmacokinetic mechanism is established.
What to do
Check ALT, AST and bilirubin at baseline and regularly during co-therapy. Interrupt or reduce therapy if liver enzymes rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Mipomersen?
MediHelp rates the interaction as moderate. Fluoxetine and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen commonly raises transaminases and can cause hepatic steatosis. Fluoxetine has been associated with occasional liver enzyme elevations, so additive hepatotoxic potential is possible.
How serious is the interaction between Fluoxetine and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ALT, AST and bilirubin at baseline and regularly during co-therapy. Interrupt or reduce therapy if liver enzymes rise significantly.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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