Drug interactions
Fluoxetine + Mobocertinib
Severity: Major
Fluoxetine and Mobocertinib: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib causes concentration-dependent QT prolongation and torsades de pointes, and fluoxetine adds some QT liability. Combined use may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Fluoxetine and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation.
What to do
Avoid the combination and choose an antidepressant with less QT effect. If it is unavoidable, reduce the mobocertinib dose and monitor ECG and electrolytes frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Mobocertinib?
MediHelp rates the interaction as major. Fluoxetine and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib causes concentration-dependent QT prolongation and torsades de pointes, and fluoxetine adds some QT liability. Combined use may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Fluoxetine and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antidepressant with less QT effect. If it is unavoidable, reduce the mobocertinib dose and monitor ECG and electrolytes frequently.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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