Drug interactions
Fluoxetine + Octreotide
Severity: Moderate
Fluoxetine and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and fluoxetine has a modest QT effect, so combined use may add to arrhythmia risk. The clinical risk is usually small in patients without other risk factors.
What this interaction means in plain words
Fluoxetine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Additive QT prolongation, with octreotide-related bradycardia contributing to proarrhythmic risk.
What to do
Obtain a baseline ECG and recheck after starting or changing doses, particularly in patients with bradycardia, electrolyte disturbance or heart disease. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluoxetine and Octreotide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Fluoxetine with Octreotide?
MediHelp rates the interaction as moderate. Fluoxetine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and fluoxetine has a modest QT effect, so combined use may add to arrhythmia risk. The clinical risk is usually small in patients without other risk factors.
How serious is the interaction between Fluoxetine and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and recheck after starting or changing doses, particularly in patients with bradycardia, electrolyte disturbance or heart disease. Correct potassium and magnesium abnormalities.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
