Drug interactions
Fluoxetine + Olodaterol inhaled
Severity: Minor
Fluoxetine and Olodaterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can prolong the QT interval, and beta2 agonists such as olodaterol can cause tachycardia, hypokalemia and QT effects. Together they may add to the risk of arrhythmia, particularly in patients with cardiac disease or electrolyte disturbances. Systemic exposure to inhaled olodaterol is low, so the risk is mostly theoretical at usual doses.
What this interaction means in plain words
Fluoxetine and Olodaterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and heart rate, with possible beta2-agonist-induced hypokalemia.
What to do
Correct potassium and magnesium before starting and monitor heart rate and ECG in patients with QT risk factors. Avoid exceeding the recommended olodaterol dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Olodaterol inhaled?
MediHelp rates the interaction as minor. Fluoxetine and Olodaterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine can prolong the QT interval, and beta2 agonists such as olodaterol can cause tachycardia, hypokalemia and QT effects. Together they may add to the risk of arrhythmia, particularly in patients with cardiac disease or electrolyte disturbances. Systemic exposure to inhaled olodaterol is low, so the risk is mostly theoretical at usual doses.
How serious is the interaction between Fluoxetine and Olodaterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before starting and monitor heart rate and ECG in patients with QT risk factors. Avoid exceeding the recommended olodaterol dose.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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