Drug interactions
Fluoxetine + Pirbuterol
Severity: Moderate
Fluoxetine and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can prolong the QT interval, and beta-2 agonists can cause tachycardia, hypokalemia and QT prolongation, mainly at higher doses. Combined use may modestly raise the risk of ventricular arrhythmias, especially in patients with other risk factors.
What this interaction means in plain words
Fluoxetine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia further increasing arrhythmia susceptibility.
What to do
Use the lowest effective pirbuterol dose and monitor ECG and serum potassium in patients with cardiac disease, electrolyte disturbances or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Pirbuterol?
MediHelp rates the interaction as moderate. Fluoxetine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can prolong the QT interval, and beta-2 agonists can cause tachycardia, hypokalemia and QT prolongation, mainly at higher doses. Combined use may modestly raise the risk of ventricular arrhythmias, especially in patients with other risk factors.
How serious is the interaction between Fluoxetine and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pirbuterol dose and monitor ECG and serum potassium in patients with cardiac disease, electrolyte disturbances or other QT-prolonging drugs.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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