Drug interactions
Fluoxetine + Quinacrine
Severity: Minor
Fluoxetine and Quinacrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6 and could raise fluoxetine levels, and both drugs have some potential to prolong the QT interval. Clinical data are very limited.
What this interaction means in plain words
Fluoxetine and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP2D6 inhibition by quinacrine; mechanism is not well characterized.
What to do
Monitor for fluoxetine adverse effects such as nausea, tremor and agitation, and consider an ECG if other QT risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Quinacrine?
MediHelp rates the interaction as minor. Fluoxetine and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinacrine may inhibit CYP2D6 and could raise fluoxetine levels, and both drugs have some potential to prolong the QT interval. Clinical data are very limited.
How serious is the interaction between Fluoxetine and Quinacrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fluoxetine adverse effects such as nausea, tremor and agitation, and consider an ECG if other QT risk factors are present.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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