Drug interactions
Fluoxetine + Salsalate
Severity: Moderate
Fluoxetine and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine and salsalate, an NSAID-type salicylate, may together increase the risk of gastrointestinal bleeding. Salsalate has weaker antiplatelet effects than aspirin, but the combined effect is still relevant in at-risk patients.
What this interaction means in plain words
Fluoxetine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk from SSRI-impaired platelet aggregation and salicylate gastric mucosal effects.
What to do
Monitor for signs of GI bleeding and consider gastroprotection in patients with ulcer history, advanced age or anticoagulant use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Salsalate?
MediHelp rates the interaction as moderate. Fluoxetine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine and salsalate, an NSAID-type salicylate, may together increase the risk of gastrointestinal bleeding. Salsalate has weaker antiplatelet effects than aspirin, but the combined effect is still relevant in at-risk patients.
How serious is the interaction between Fluoxetine and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and consider gastroprotection in patients with ulcer history, advanced age or anticoagulant use.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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