Drug interactions
Fluoxetine + Thiothixene
Severity: Moderate
Fluoxetine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval, and fluoxetine inhibits CYP2D6, which may increase antipsychotic exposure. The combination raises the risk of arrhythmia and also of extrapyramidal effects.
What this interaction means in plain words
Fluoxetine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with fluoxetine CYP2D6 inhibition possibly raising thiothixene levels.
What to do
Monitor ECG and electrolytes, and watch for extrapyramidal symptoms and sedation. Consider a lower thiothixene dose when starting fluoxetine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Thiothixene?
MediHelp rates the interaction as moderate. Fluoxetine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QT interval, and fluoxetine inhibits CYP2D6, which may increase antipsychotic exposure. The combination raises the risk of arrhythmia and also of extrapyramidal effects.
How serious is the interaction between Fluoxetine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for extrapyramidal symptoms and sedation. Consider a lower thiothixene dose when starting fluoxetine.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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