Drug interactions
Fluoxetine + Vilanterol / fluticasone furoate inhaled
Severity: Minor
Fluoxetine and Vilanterol / fluticasone furoate inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can prolong the QT interval and vilanterol, a long-acting beta2 agonist, can cause tachycardia and lower potassium. Inhaled systemic exposure is low, so clinically important effects are uncommon but possible in at-risk patients.
What this interaction means in plain words
Fluoxetine and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and heart rate.
What to do
Monitor for palpitations and check ECG and potassium in patients with underlying cardiac disease. Use the inhaler at the labeled dose only.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as minor. Fluoxetine and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine can prolong the QT interval and vilanterol, a long-acting beta2 agonist, can cause tachycardia and lower potassium. Inhaled systemic exposure is low, so clinically important effects are uncommon but possible in at-risk patients.
How serious is the interaction between Fluoxetine and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and check ECG and potassium in patients with underlying cardiac disease. Use the inhaler at the labeled dose only.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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