Drug interactions
Fluoxetine + Vorapaxar
Severity: Moderate
Fluoxetine and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs such as fluoxetine impair platelet serotonin uptake and can increase bleeding tendency, which adds to the antiplatelet effect of vorapaxar. The risk of clinically significant bleeding is therefore higher.
What this interaction means in plain words
Fluoxetine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function via serotonin depletion and PAR-1 antagonism.
What to do
Monitor for signs of bleeding, especially gastrointestinal, and reassess the need for each agent. Consider gastroprotection in patients at high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Vorapaxar?
MediHelp rates the interaction as moderate. Fluoxetine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs such as fluoxetine impair platelet serotonin uptake and can increase bleeding tendency, which adds to the antiplatelet effect of vorapaxar. The risk of clinically significant bleeding is therefore higher.
How serious is the interaction between Fluoxetine and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, especially gastrointestinal, and reassess the need for each agent. Consider gastroprotection in patients at high bleeding risk.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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