Drug interactions
Flurazepam + Methocarbamol
Severity: Moderate
Flurazepam and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting hypnotic benzodiazepine with active metabolites. With methocarbamol, daytime drowsiness, impaired coordination, falls and respiratory depression may be increased.
What this interaction means in plain words
Flurazepam and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and methocarbamol's central depressant effect.
What to do
Use the lowest effective doses and monitor for oversedation, especially in older adults. Advise against driving and other hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Frequently asked questions
Can I take Flurazepam with Methocarbamol?
MediHelp rates the interaction as moderate. Flurazepam and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting hypnotic benzodiazepine with active metabolites. With methocarbamol, daytime drowsiness, impaired coordination, falls and respiratory depression may be increased.
How serious is the interaction between Flurazepam and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation, especially in older adults. Advise against driving and other hazardous activities.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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