Drug interactions
Flurazepam + Orphenadrin
Severity: Moderate
Flurazepam and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine hypnotic with a active metabolite, and orphenadrine adds sedation and anticholinergic effects. Together they may increase drowsiness, dizziness, confusion and psychomotor impairment, especially in older adults.
What this interaction means in plain words
Flurazepam and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression via GABA-A potentiation and central anticholinergic activity.
What to do
Use the lowest effective doses and warn the patient about driving and operating machinery; in older patients avoid the combination where possible because of fall and delirium risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Frequently asked questions
Can I take Flurazepam with Orphenadrin?
MediHelp rates the interaction as moderate. Flurazepam and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine hypnotic with a active metabolite, and orphenadrine adds sedation and anticholinergic effects. Together they may increase drowsiness, dizziness, confusion and psychomotor impairment, especially in older adults.
How serious is the interaction between Flurazepam and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn the patient about driving and operating machinery; in older patients avoid the combination where possible because of fall and delirium risk.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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