Drug interactions
Flurazepam + Thioridazine
Severity: Moderate
Flurazepam and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam and thioridazine both depress the CNS, so together they can intensify sedation and impair psychomotor performance. The long-acting flurazepam metabolite may prolong the effect, particularly in older adults.
What this interaction means in plain words
Flurazepam and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and monitor for oversedation and falls. Consider a shorter-acting alternative in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Flurazepam with Thioridazine?
MediHelp rates the interaction as moderate. Flurazepam and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam and thioridazine both depress the CNS, so together they can intensify sedation and impair psychomotor performance. The long-acting flurazepam metabolite may prolong the effect, particularly in older adults.
How serious is the interaction between Flurazepam and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and falls. Consider a shorter-acting alternative in older patients.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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