Drug interactions
Flurbiprofen + Gliclazide
Severity: Moderate
Flurbiprofen and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen may increase the hypoglycemic effect of gliclazide. Flurbiprofen is a CYP2C9 substrate, so competition may also occur. Hypoglycemia is the main concern.
What this interaction means in plain words
Flurbiprofen and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Gliclazide belongs to Endocrine.
Why it happens
Possible protein-binding displacement and competition for CYP2C9 metabolism; not firmly established.
What to do
Monitor blood glucose during co-administration, especially in elderly or renally impaired patients. Adjust the gliclazide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Gliclazide?
MediHelp rates the interaction as moderate. Flurbiprofen and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen may increase the hypoglycemic effect of gliclazide. Flurbiprofen is a CYP2C9 substrate, so competition may also occur. Hypoglycemia is the main concern.
How serious is the interaction between Flurbiprofen and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during co-administration, especially in elderly or renally impaired patients. Adjust the gliclazide dose if glucose falls.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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