Drug interactions
Flurbiprofen + Glipizide-metformin
Severity: Moderate
Flurbiprofen and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen may potentiate sulfonylurea glucose lowering and cause hypoglycemia. Flurbiprofen is a CYP2C9 substrate, so competition at this enzyme may contribute. NSAID-related renal impairment may also affect metformin handling.
What this interaction means in plain words
Flurbiprofen and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Glipizide-metformin belongs to Endocrine.
Why it happens
Possible competition for CYP2C9 metabolism and protein binding; NSAIDs can also reduce renal clearance via prostaglandin inhibition.
What to do
Monitor blood glucose and renal function when starting or stopping flurbiprofen. Reduce the glipizide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Glipizide-metformin?
MediHelp rates the interaction as moderate. Flurbiprofen and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen may potentiate sulfonylurea glucose lowering and cause hypoglycemia. Flurbiprofen is a CYP2C9 substrate, so competition at this enzyme may contribute. NSAID-related renal impairment may also affect metformin handling.
How serious is the interaction between Flurbiprofen and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when starting or stopping flurbiprofen. Reduce the glipizide dose if hypoglycemia develops.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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