Drug interactions
Flurbiprofen + Glyburide-metformin
Severity: Moderate
Flurbiprofen and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen may enhance the hypoglycemic effect of glyburide. NSAID-related renal impairment may also increase the risk of metformin accumulation.
What this interaction means in plain words
Flurbiprofen and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Glyburide-metformin belongs to Endocrine.
Why it happens
Competition for CYP2C9 metabolism and protein binding, plus NSAID-related reduction in renal function.
What to do
Monitor blood glucose when starting or stopping flurbiprofen and reduce the glyburide dose if needed. Check renal function with prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Glyburide-metformin?
MediHelp rates the interaction as moderate. Flurbiprofen and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen may enhance the hypoglycemic effect of glyburide. NSAID-related renal impairment may also increase the risk of metformin accumulation.
How serious is the interaction between Flurbiprofen and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping flurbiprofen and reduce the glyburide dose if needed. Check renal function with prolonged use.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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