Drug interactions
Flurbiprofen + Hydrochlorothiazide-telmisartan
Severity: Major
Flurbiprofen and Hydrochlorothiazide-telmisartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen can weaken the antihypertensive effect of telmisartan and hydrochlorothiazide. The combination raises the risk of acute kidney injury, especially in elderly or volume-depleted patients, and can contribute to hyperkalemia.
What this interaction means in plain words
Flurbiprofen and Hydrochlorothiazide-telmisartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flurbiprofen belongs to Musculoskeletal; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of prostaglandin synthesis reduces renal perfusion and promotes sodium retention, while ARB blockade impairs compensatory efferent arteriolar tone.
What to do
Avoid combined use when possible, or limit the NSAID to the lowest effective dose and duration. Monitor blood pressure, serum creatinine and potassium and ensure adequate hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flurbiprofen and Hydrochlorothiazide-telmisartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as major. Flurbiprofen and Hydrochlorothiazide-telmisartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Flurbiprofen can weaken the antihypertensive effect of telmisartan and hydrochlorothiazide. The combination raises the risk of acute kidney injury, especially in elderly or volume-depleted patients, and can contribute to hyperkalemia.
How serious is the interaction between Flurbiprofen and Hydrochlorothiazide-telmisartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use when possible, or limit the NSAID to the lowest effective dose and duration. Monitor blood pressure, serum creatinine and potassium and ensure adequate hydration.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
