Drug interactions
Flurbiprofen + Ibrutinib
Severity: Major
Flurbiprofen and Ibrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and is linked to bleeding events, and flurbiprofen adds antiplatelet activity and gastrointestinal mucosal injury. Together the risk of hemorrhage, including serious GI bleeding, is increased.
What this interaction means in plain words
Flurbiprofen and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flurbiprofen belongs to Musculoskeletal; Ibrutinib belongs to Oncology.
Why it happens
Additive impairment of platelet function (BTK inhibition plus COX inhibition) and NSAID-related mucosal damage.
What to do
Avoid concurrent NSAIDs where possible and use paracetamol for analgesia. If the combination is unavoidable, monitor for bleeding signs and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Flurbiprofen with Ibrutinib?
MediHelp rates the interaction as major. Flurbiprofen and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibrutinib impairs platelet function and is linked to bleeding events, and flurbiprofen adds antiplatelet activity and gastrointestinal mucosal injury. Together the risk of hemorrhage, including serious GI bleeding, is increased.
How serious is the interaction between Flurbiprofen and Ibrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent NSAIDs where possible and use paracetamol for analgesia. If the combination is unavoidable, monitor for bleeding signs and consider gastroprotection.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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