Drug interactions
Flurbiprofen + Ketoconazole
Severity: Minor
Flurbiprofen and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may modestly increase flurbiprofen exposure through CYP2C9 inhibition, with possible increased NSAID adverse effects. The evidence is limited because ketoconazole is mainly a CYP3A4 inhibitor.
What this interaction means in plain words
Flurbiprofen and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flurbiprofen belongs to Musculoskeletal; Ketoconazole belongs to Anti Fungals.
Why it happens
Possible inhibition of CYP2C9-mediated flurbiprofen metabolism.
What to do
Use the lowest effective flurbiprofen dose and monitor for GI or renal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Ketoconazole?
MediHelp rates the interaction as minor. Flurbiprofen and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may modestly increase flurbiprofen exposure through CYP2C9 inhibition, with possible increased NSAID adverse effects. The evidence is limited because ketoconazole is mainly a CYP3A4 inhibitor.
How serious is the interaction between Flurbiprofen and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective flurbiprofen dose and monitor for GI or renal adverse effects.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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