Drug interactions
Flurbiprofen + Nilotinib
Severity: Minor
Flurbiprofen and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP2C9 in vitro and may raise flurbiprofen exposure, increasing NSAID adverse effects. NSAIDs may also add to bleeding tendency with nilotinib-related thrombocytopenia.
What this interaction means in plain words
Flurbiprofen and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flurbiprofen belongs to Musculoskeletal; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibition of CYP2C9-mediated flurbiprofen metabolism, demonstrated mainly in vitro.
What to do
Use the lowest effective flurbiprofen dose and monitor for bleeding and GI adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Nilotinib?
MediHelp rates the interaction as minor. Flurbiprofen and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits CYP2C9 in vitro and may raise flurbiprofen exposure, increasing NSAID adverse effects. NSAIDs may also add to bleeding tendency with nilotinib-related thrombocytopenia.
How serious is the interaction between Flurbiprofen and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective flurbiprofen dose and monitor for bleeding and GI adverse effects.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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