Drug interactions
Flurbiprofen + Ofloxacin
Severity: Moderate
Flurbiprofen and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can lower the seizure threshold, and NSAIDs may add to this effect in susceptible patients. Seizures are uncommon but serious, especially in those with epilepsy, renal impairment or other predisposing factors.
What this interaction means in plain words
Flurbiprofen and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones antagonise GABA-A receptor binding, and NSAIDs may potentiate this effect, increasing CNS excitability.
What to do
Avoid the combination in patients with a seizure history or other risk factors, and consider another analgesic. Counsel patients to report tremor, confusion or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Flurbiprofen with Ofloxacin?
MediHelp rates the interaction as moderate. Flurbiprofen and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can lower the seizure threshold, and NSAIDs may add to this effect in susceptible patients. Seizures are uncommon but serious, especially in those with epilepsy, renal impairment or other predisposing factors.
How serious is the interaction between Flurbiprofen and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with a seizure history or other risk factors, and consider another analgesic. Counsel patients to report tremor, confusion or seizures.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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