Drug interactions
Flurbiprofen + Paroxetine
Severity: Moderate
Flurbiprofen and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with an NSAID substantially increases the risk of upper gastrointestinal bleeding compared with either drug alone. The risk is greater in older patients and those with prior ulcers.
What this interaction means in plain words
Flurbiprofen and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
SSRIs deplete platelet serotonin impairing aggregation, while NSAIDs inhibit platelet thromboxane and damage gastric mucosa.
What to do
Consider a proton pump inhibitor for gastroprotection in at-risk patients and counsel on signs of GI bleeding. Use the lowest effective NSAID dose or an alternative analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Paroxetine?
MediHelp rates the interaction as moderate. Flurbiprofen and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with an NSAID substantially increases the risk of upper gastrointestinal bleeding compared with either drug alone. The risk is greater in older patients and those with prior ulcers.
How serious is the interaction between Flurbiprofen and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor for gastroprotection in at-risk patients and counsel on signs of GI bleeding. Use the lowest effective NSAID dose or an alternative analgesic where possible.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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