Drug interactions
Flurbiprofen + Siponimod
Severity: Minor
Flurbiprofen and Siponimod: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen is a CYP2C9 substrate with weak to modest inhibitory activity and is not a recognized meaningful CYP2C9 inhibitor, so a clinically significant rise in siponimod exposure is unlikely. The labeled restriction applies to combined moderate CYP2C9 and CYP3A4 inhibitors, which flurbiprofen is not.
What this interaction means in plain words
Flurbiprofen and Siponimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flurbiprofen belongs to Musculoskeletal; Siponimod belongs to Central Nervous System.
Why it happens
Both drugs are CYP2C9 substrates, so minor competition for metabolism is theoretically possible.
What to do
No dose change is needed; be aware of the shared pathway and monitor for siponimod adverse effects such as bradycardia if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Siponimod?
MediHelp rates the interaction as minor. Flurbiprofen and Siponimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Flurbiprofen is a CYP2C9 substrate with weak to modest inhibitory activity and is not a recognized meaningful CYP2C9 inhibitor, so a clinically significant rise in siponimod exposure is unlikely. The labeled restriction applies to combined moderate CYP2C9 and CYP3A4 inhibitors, which flurbiprofen is not.
How serious is the interaction between Flurbiprofen and Siponimod?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; be aware of the shared pathway and monitor for siponimod adverse effects such as bradycardia if symptoms occur.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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