Drug interactions
Flurbiprofen + Streptomycin
Severity: Moderate
Flurbiprofen and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, as shown mainly in preterm infants given indomethacin or ibuprofen for ductus closure. Higher aminoglycoside levels raise the risk of nephrotoxicity and ototoxicity.
What this interaction means in plain words
Flurbiprofen and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
NSAIDs inhibit prostaglandin-dependent renal blood flow, reducing glomerular filtration and aminoglycoside clearance.
What to do
Monitor renal function and streptomycin levels when the combination is used, and keep the NSAID course short and well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Flurbiprofen with Streptomycin?
MediHelp rates the interaction as moderate. Flurbiprofen and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal clearance of aminoglycosides, as shown mainly in preterm infants given indomethacin or ibuprofen for ductus closure. Higher aminoglycoside levels raise the risk of nephrotoxicity and ototoxicity.
How serious is the interaction between Flurbiprofen and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and streptomycin levels when the combination is used, and keep the NSAID course short and well hydrated.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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