Drug interactions
Flurbiprofen + Tenecteplase
Severity: Major
Flurbiprofen and Tenecteplase: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenecteplase is a thrombolytic that carries a substantial bleeding risk. Flurbiprofen inhibits platelet function and can injure the gastric mucosa, which further raises the risk of hemorrhage.
What this interaction means in plain words
Flurbiprofen and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flurbiprofen belongs to Musculoskeletal; Tenecteplase belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects: fibrinolysis plus NSAID-induced platelet inhibition and mucosal injury.
What to do
Weigh the risk of bleeding carefully before thrombolysis in patients taking NSAIDs and monitor closely for bleeding. Avoid NSAIDs in the period after thrombolysis where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Flurbiprofen with Tenecteplase?
MediHelp rates the interaction as major. Flurbiprofen and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenecteplase is a thrombolytic that carries a substantial bleeding risk. Flurbiprofen inhibits platelet function and can injure the gastric mucosa, which further raises the risk of hemorrhage.
How serious is the interaction between Flurbiprofen and Tenecteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Weigh the risk of bleeding carefully before thrombolysis in patients taking NSAIDs and monitor closely for bleeding. Avoid NSAIDs in the period after thrombolysis where possible.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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