Drug interactions
Flurbiprofen + Triamterene
Severity: Major
Flurbiprofen and Triamterene: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with triamterene increases the risk of hyperkalemia and of acute kidney injury. NSAIDs also reduce the diuretic effect.
What this interaction means in plain words
Flurbiprofen and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flurbiprofen belongs to Musculoskeletal; Triamterene belongs to Cardiovascular.
Why it happens
NSAIDs reduce renal prostaglandin synthesis and perfusion, impairing potassium excretion, while triamterene blocks distal sodium channels and reduces potassium secretion.
What to do
Avoid if possible, particularly in renal impairment or the elderly. If used together, monitor serum potassium and renal function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Flurbiprofen with Triamterene?
MediHelp rates the interaction as major. Flurbiprofen and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with triamterene increases the risk of hyperkalemia and of acute kidney injury. NSAIDs also reduce the diuretic effect.
How serious is the interaction between Flurbiprofen and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, particularly in renal impairment or the elderly. If used together, monitor serum potassium and renal function closely.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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