Drug interactions
Fluticasone + Idelalisib
Severity: Major
Fluticasone and Idelalisib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and can substantially increase systemic fluticasone exposure. This raises the risk of Cushing syndrome and adrenal suppression.
What this interaction means in plain words
Fluticasone and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone belongs to Respiratory; Idelalisib belongs to Oncology.
Why it happens
Idelalisib strongly inhibits CYP3A4, reducing fluticasone clearance.
What to do
Avoid prolonged coadministration and consider beclomethasone as an alternative. If used together, monitor for corticosteroid systemic effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Fluticasone with Idelalisib?
MediHelp rates the interaction as major. Fluticasone and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A4 inhibitor and can substantially increase systemic fluticasone exposure. This raises the risk of Cushing syndrome and adrenal suppression.
How serious is the interaction between Fluticasone and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged coadministration and consider beclomethasone as an alternative. If used together, monitor for corticosteroid systemic effects.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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