Drug interactions
Fluticasone + Fosphenytoin
Severity: Moderate
Fluticasone and Fosphenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosphenytoin is converted to phenytoin, a CYP3A4 inducer, which can lower fluticasone exposure. Reduced anti-inflammatory effect may cause worsening asthma or rhinitis control.
What this interaction means in plain words
Fluticasone and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone belongs to Respiratory; Fosphenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4, increasing fluticasone metabolism.
What to do
Monitor asthma or allergy control and adjust the fluticasone dose if symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone and Fosphenytoin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fluticasone with Fosphenytoin?
MediHelp rates the interaction as moderate. Fluticasone and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosphenytoin is converted to phenytoin, a CYP3A4 inducer, which can lower fluticasone exposure. Reduced anti-inflammatory effect may cause worsening asthma or rhinitis control.
How serious is the interaction between Fluticasone and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma or allergy control and adjust the fluticasone dose if symptoms worsen.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
