Drug interactions

Fluticasone + Indinavir

Severity: Major

Fluticasone and Indinavir: major interaction.

Last updated 29 Oct 2026 Sources: US FDA label

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Indinavir inhibits CYP3A4 and may raise fluticasone concentrations. Systemic corticosteroid effects including adrenal suppression are possible with prolonged use.

Fluticasone

What this interaction means in plain words

Fluticasone and Indinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Evidence level: Moderate

Why it happens

Indinavir inhibits CYP3A4, reducing fluticasone clearance.

What to do

Prefer a corticosteroid less reliant on CYP3A4, such as beclomethasone, for long-term use. If combined, monitor for signs of hypercortisolism.

What to ask your pharmacist

Does the benefit of taking both outweigh the risk in my case?
Do I need any blood test, ECG or other check while on both?
What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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References

Fluticasone Propionate and Salmeterol - FDA drug label (DailyMed) - section 7 Drug Interactions (names the partner; "he individual components of this product, are substrates of CYP3A4. The use of strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir,") — DailyMed (FDA label)

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Frequently asked questions

Can I take Fluticasone with Indinavir?

MediHelp rates the interaction as major. Fluticasone and Indinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indinavir inhibits CYP3A4 and may raise fluticasone concentrations. Systemic corticosteroid effects including adrenal suppression are possible with prolonged use.

How serious is the interaction between Fluticasone and Indinavir?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a corticosteroid less reliant on CYP3A4, such as beclomethasone, for long-term use. If combined, monitor for signs of hypercortisolism.

What other medicines interact with Fluticasone?

MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.

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