Drug interactions
Fluticasone + Isoniazid
Severity: Minor
Fluticasone and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak CYP3A4 inhibitor and is unlikely to raise fluticasone exposure meaningfully. A clinically significant effect has not been well documented.
What this interaction means in plain words
Fluticasone and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone belongs to Respiratory; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak, inconsistent CYP3A4 inhibition by isoniazid may slightly reduce fluticasone clearance.
What to do
No routine action is needed; be aware of possible corticosteroid excess if symptoms of Cushing syndrome appear during long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone
Other interactions of Isoniazid
Frequently asked questions
Can I take Fluticasone with Isoniazid?
MediHelp rates the interaction as minor. Fluticasone and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak CYP3A4 inhibitor and is unlikely to raise fluticasone exposure meaningfully. A clinically significant effect has not been well documented.
How serious is the interaction between Fluticasone and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; be aware of possible corticosteroid excess if symptoms of Cushing syndrome appear during long-term use.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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