Drug interactions
Fluticasone + Phenobarbital
Severity: Moderate
Fluticasone and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces CYP3A4 and may lower fluticasone exposure, potentially reducing efficacy.
What this interaction means in plain words
Fluticasone and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Phenobarbital induces CYP3A4, increasing fluticasone metabolism.
What to do
Monitor asthma or allergy control and increase fluticasone dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone
Frequently asked questions
Can I take Fluticasone with Phenobarbital?
MediHelp rates the interaction as moderate. Fluticasone and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital induces CYP3A4 and may lower fluticasone exposure, potentially reducing efficacy.
How serious is the interaction between Fluticasone and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma or allergy control and increase fluticasone dose if control worsens.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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