Drug interactions
Fluticasone furoate + Imatinib
Severity: Moderate
Fluticasone furoate and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and may moderately increase exposure to fluticasone furoate. Increased systemic corticosteroid effects such as adrenal suppression are possible during extended co-use.
What this interaction means in plain words
Fluticasone furoate and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Imatinib inhibits CYP3A4, reducing metabolic clearance of fluticasone furoate.
What to do
Monitor for systemic corticosteroid adverse effects with long-term co-administration. Use the lowest effective fluticasone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone furoate and Imatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Fluticasone furoate with Imatinib?
MediHelp rates the interaction as moderate. Fluticasone furoate and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4 and may moderately increase exposure to fluticasone furoate. Increased systemic corticosteroid effects such as adrenal suppression are possible during extended co-use.
How serious is the interaction between Fluticasone furoate and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid adverse effects with long-term co-administration. Use the lowest effective fluticasone dose.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
