Drug interactions
Fluticasone furoate + Lenacapavir
Severity: Moderate
Fluticasone furoate and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor, and its effect can persist for months after subcutaneous dosing. It may increase fluticasone furoate exposure and the chance of systemic corticosteroid effects.
What this interaction means in plain words
Fluticasone furoate and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lenacapavir inhibits CYP3A4, reducing fluticasone clearance.
What to do
Monitor for signs of corticosteroid excess during long-term co-use; consider beclomethasone as an alternative if prolonged therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fluticasone furoate with Lenacapavir?
MediHelp rates the interaction as moderate. Fluticasone furoate and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor, and its effect can persist for months after subcutaneous dosing. It may increase fluticasone furoate exposure and the chance of systemic corticosteroid effects.
How serious is the interaction between Fluticasone furoate and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess during long-term co-use; consider beclomethasone as an alternative if prolonged therapy is needed.
What other medicines interact with Lenacapavir?
MediHelp also lists interactions of Lenacapavir with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Lenacapavir page.
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