Drug interactions
Fluticasone furoate + Mitotane
Severity: Moderate
Fluticasone furoate and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and may reduce fluticasone furoate concentrations, potentially weakening its effect. Mitotane also suppresses adrenal function, which complicates corticosteroid management.
What this interaction means in plain words
Fluticasone furoate and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mitotane induces CYP3A4, increasing fluticasone clearance.
What to do
Monitor disease control and consider a higher dose or alternative therapy if response is lost; remain alert to adrenal insufficiency in mitotane-treated patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Fluticasone furoate with Mitotane?
MediHelp rates the interaction as moderate. Fluticasone furoate and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and may reduce fluticasone furoate concentrations, potentially weakening its effect. Mitotane also suppresses adrenal function, which complicates corticosteroid management.
How serious is the interaction between Fluticasone furoate and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease control and consider a higher dose or alternative therapy if response is lost; remain alert to adrenal insufficiency in mitotane-treated patients.
What other medicines interact with Mitotane?
MediHelp also lists interactions of Mitotane with, for example, Doravirine, Fostemsavir, Lorlatinib. The full list is on the Mitotane page.
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