Drug interactions
Fluticasone furoate + Nicardipine
Severity: Minor
Fluticasone furoate and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak to moderate CYP3A4 inhibitor and could modestly raise fluticasone furoate levels. A clinically important effect is unlikely at usual inhaled or intranasal doses.
What this interaction means in plain words
Fluticasone furoate and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mild CYP3A4 inhibition by nicardipine decreases fluticasone furoate metabolism.
What to do
No routine adjustment is needed. Watch for systemic corticosteroid effects in patients on long-term high-dose therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Fluticasone furoate with Nicardipine?
MediHelp rates the interaction as minor. Fluticasone furoate and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a weak to moderate CYP3A4 inhibitor and could modestly raise fluticasone furoate levels. A clinically important effect is unlikely at usual inhaled or intranasal doses.
How serious is the interaction between Fluticasone furoate and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for systemic corticosteroid effects in patients on long-term high-dose therapy.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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