Drug interactions
Fluticasone inhaled + Imatinib
Severity: Moderate
Fluticasone inhaled and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and may increase systemic fluticasone exposure. Raised exposure could lead to systemic corticosteroid effects such as adrenal suppression, though imatinib is a weaker inhibitor than ritonavir or ketoconazole.
What this interaction means in plain words
Fluticasone inhaled and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Imatinib inhibits CYP3A4, reducing first-pass and systemic clearance of fluticasone.
What to do
Monitor for signs of corticosteroid excess with long-term use; consider an alternative inhaled steroid such as beclomethasone if concerns arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Fluticasone inhaled with Imatinib?
MediHelp rates the interaction as moderate. Fluticasone inhaled and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4 and may increase systemic fluticasone exposure. Raised exposure could lead to systemic corticosteroid effects such as adrenal suppression, though imatinib is a weaker inhibitor than ritonavir or ketoconazole.
How serious is the interaction between Fluticasone inhaled and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess with long-term use; consider an alternative inhaled steroid such as beclomethasone if concerns arise.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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