Drug interactions
Fluticasone inhaled + Mifepristone
Severity: Moderate
Fluticasone inhaled and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibitors can substantially increase systemic fluticasone exposure, and mifepristone is a CYP3A4 inhibitor. This may cause Cushing-like effects and adrenal suppression. Mifepristone's glucocorticoid receptor blockade complicates the clinical picture.
What this interaction means in plain words
Fluticasone inhaled and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mifepristone inhibits CYP3A4, reducing first-pass and systemic clearance of fluticasone.
What to do
Monitor for signs of systemic corticosteroid excess and for asthma control. Consider a less CYP3A4-dependent corticosteroid if long-term use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Fluticasone inhaled with Mifepristone?
MediHelp rates the interaction as moderate. Fluticasone inhaled and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inhibitors can substantially increase systemic fluticasone exposure, and mifepristone is a CYP3A4 inhibitor. This may cause Cushing-like effects and adrenal suppression. Mifepristone's glucocorticoid receptor blockade complicates the clinical picture.
How serious is the interaction between Fluticasone inhaled and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of systemic corticosteroid excess and for asthma control. Consider a less CYP3A4-dependent corticosteroid if long-term use is needed.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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